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ea0016p307 | Endocrine tumours | ECE2008

VDR gene polymorphisms in patients with differentiated thyroid cancer

Penna-Martinez Marissa , Stern Julienne , Kahles Heinrich , Reusch Jurgen , Hinsch Nora , Hansmann Martin-Leo , Selkinski Ivan , Grunwald Frank , Wahl Robert , Holzer Katharina , Ramos-Lopez Elizabeth , Badenhoop Klaus

Background/aim: Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is thought to represent an important endogenous response to tumor progression. Therefore, in order to evaluate the role of VDR-gene and of the 25(OH)-Vitamin D3 in thyroid cancer we analysed four polymorphisms in patients with thyroid cancer and healthy controls.Patients and methods: Patients (n=136; 84 females and 52 males) with d...

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ea0022p381 | Endocrine tumours & neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

CYP24A1 haplotypes are associated with differentiated thyroid carcinoma

Penna-Martinez Marissa , Ramos-Lopez Elizabeth , Stern Julienne , Kahles Heinrich , Hinsch Nora , Hansmann Martin-Leo , Selkinski Ivan , Grunwald Frank , Vorlander Christian , Wahl Robert A , Bechstein Wolf O , Zeuzem Stefan , Holzer Katharina , Badenhoop Klaus

Background: Previously, we reported an association of vitamin D receptor (VDR) polymorphisms and differentiated thyroid cancer (DTC) risk. The aim of the present study was to investigate other vitamin D pathway genes such as CYP27B1, CYP2R1 and CYP24A1 which code for enzymes that, respectively, synthesize and degrade 1,25(OH)2D3 in patients with DTC and healthy controls (HC). Also its influence on 25(OH)D3 and 1,25(OH)2D3 ...

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Endocrine Abstracts

VDR gene polymorphisms in patients with differentiated thyroid cancer

CYP24A1 haplotypes are associated with differentiated thyroid carcinoma

BiosciAbstracts